How to comfort a dear friend going thru a rough time?

My very best friend has always led a stressful life, but recenlty its gotten even worse, he married a extremely controlling woman even tho they've fought since day one, he felt pushed into doing it and also he recently turned 30 which he thinks is "old" so he just went for it...well now he's waking up a little and wanting a divorce but he even sees that as depressing & a failure though hes not to blame cause i know he tried his very best & shes not easy to tolerate at all... anyway he's pretty low and getting reclusive, this isnt even the same person Ive known the past 10 years...he says no offense but I just want to be left alone which i can understand but im so scared he'll do something deperate, of course I dont want to bug him but I know sometimes people say that just to see whos willing to break thru the walls & show they truly care, should I just sit here idolly as he requested or is there a way I can cheer him up without being pushy??